Doubling up on NSAIDs (for example taking Aleve and Advil at the same time) is unnecessary, and to be avoided as it increases the risk of both GI and cardiovascular side effects. To reduce the risk of GI side effects, NSAIDS should only be taken at their lowest effective dose, for the shortest possible time. Aleve is more likely than Advil to cause GI side effects because it is longer acting. Research has discovered that the risk of gastrointestinal (GI) side effects such as stomach ulcers and stomach bleeding increases the longer somebody takes NSAIDS. It has a slower onset of effect and is better suited for the treatment of chronic conditions.Īleve is More Likely to Cause Gastrointestinal Side Effects Because it is Long Acting

Aleve is considered long-acting, and can be given twice daily. Advil tablets/capsules need to be given every four to six hours. It is better suited for the treatment of acute pain and is the most appropriate NSAID for children. Advil is considered a short-acting NSAID, with a relatively quick onset of action. One of the most important differences is the length of time Aleve and Advil act for. As far as effectiveness goes, a dose of 440mg Aleve is approximately equivalent to a dose of 400mg Advil.Īleve is Long Acting and Advil is Short Acting This makes them effective at relieving pain and reducing inflammation, but there is a risk of stomach-related side effects. Naproxen and ibuprofen are both NSAIDs so they are similar in many ways, but there are important differences.Īleve and Advil are called nonselective NSAIDs because they block COX-2 enzymes (involved in pain signalling and inflammation) and also COX-1 enzymes (associated with a protective effect on stomach lining). Aleve is more likely than Advil to cause gastrointestinal (GI) side effects because it is longer acting.Īleve is a brand (trade) name for naproxen and Advil is a brand (trade) name for ibuprofen. Aleve is better suited for the treatment of chronic conditions.

Advil is better suited for the treatment of acute pain and is the most appropriate NSAID for children. Aleve is long acting and Advil is short acting.

Advil minis